Clear Health Pass™ Blog

Omicron

What You Need to Know:  Omicron (B.1.1.529) South African Variant  Clear Health Pass Covid Pandemic Update: December 06, 2022   The B.1.1.529 variant was first

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Study: Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous

Monocytes are a group of immune cells that originate in bone marrow and are released into peripheral blood, where they circulate for several days1,2. They belong to the mononuclear-phagocyte system, which also include macrophages, dendritic cells and their bone-marrow precursors3,4,5. Monocytes represent 5–10% of peripheral leucocytes and are probably best known for serving as a systemic reservoir of myeloid precursors that are needed for the renewal of tissue macrophages and dendritic cells6,7,8,9. However, they also have other well documented functions in immune response against infection10,11,12,13 and in pathogenesis of several inflammatory disorders. Although initially perceived as a homogeneous population, it has become increasingly apparent that monocytes display considerable heterogeneity with respect to their phenotype and function1,2,14,15.

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Study: CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes

Immunoglobulin G (IgG) antibody subclasses play major roles in the control of bacterial and viral infections, the killing of tumour cells during antibody therapy and the pathological destruction of healthy tissues in autoimmune diseases. As a result of their potency and range of actions, antibodies have become one of the most rapidly growing classes of human therapeutics in recent years, particularly in cancer treatments.

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Study: Optical Biosensors for Virus Detection: Prospects for SARS-CoV-2/COVID-19

Optical biosensors have led to significant advancements in virus detection and imaging capabilities. Coupled with advanced instrumentation, they have enabled higher sensitivities while increasing the rate at which samples can be tested. These techniques can be developed into point-of-care (POC) diagnostics for viral detection and are promising alternatives to detect COVID-19.

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Study: SARS-CoV-2 Transmission From People Without COVID-19 Symptoms

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the etiology of coronavirus disease 2019 (COVID-19), is readily transmitted person to person. Optimal control of COVID-19 depends on directing resources and health messaging to mitigation efforts that are most likely to prevent transmission, but the relative importance of such measures has been disputed.

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Study: Lateral flow tests cannot rule out SARS- CoV-2 infection

Lateral flow devices for asymptomatic mass testing are proving controversial. At the heart of the matter is a flawed process, with the decision to implement society-wide “Moonshot” testing made before robust field evaluations of the tests were completed. Subsequent selective emphasis of unrealistic performance estimates has caused confusion. Little surprise we are now in a mess.

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