Our understanding of the epidemiology of the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection and associated COVID-19 illness continues to evolve. Statistics from early in the pandemic indicate that ~1 in 5 infected individuals are hospitalized, and 1 in 10 may be admitted to an intensive care unit (ICU), with most of these critically ill patients experiencing acute respiratory distress syndrome (ARDS) and requiring mechanical ventilation.