Study: Frequent neurologic manifestations and encephalopathy-associated morbidity in Covid-19 patients

Covid-19 can involve multiple organs including the nervous system. We sought to characterize the neurologic manifestations, their risk factors, and associated outcomes in hospitalized patients with Covid-19.

Article: The tragedy of long COVID

Tens of thousands of people in the United States have lingering illness following COVID-19. In the US, we call them post-COVID “long haulers.” Currently, the condition they are suffering from is known as “long COVID,” although other names are being proposed.

Study: Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Numerous variants of SARS-CoV-2-harboring mutations in spike have arisen globally
mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus

Study: SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

SARS-CoV-2 entry is mediated by the spike (S) glycoprotein which contains the receptor-binding domain (RBD) and the N-terminal domain (NTD) as the two main targets of neutralizing antibodies (Abs). A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429) was originally detected in California and is currently spreading throughout the US and 29 additional countries. It is unclear whether antibody responses to SARS-CoV-2 infection or to the prototypic Wuhan-1 isolate-based vaccines will be impacted by the three B.1.427/B.1.429 S mutations: S13I, W152C and L452R. 

Long COVID (Post-Acute Sequelae of SARS CoV-2 infection, PASC)

Long COVID, or what doctors refer to as post-acute sequelae of COVID-19 (PASC), is a condition marked by the continuation of COVID-19 symptoms—or the emergence of new ones—after recovery from acute (or the initial phase of illness of) COVID-19.

CDC to Issue Guidelines As Long-Haul COVID Numbers Rise

The CDC is finalizing new guidelines for doctors on long-haul COVID-19.

Study: COVID-19 Can Kill Months After Infection

Long-haul COVID-19 patients face many health threats — including a higher chance of dying — up to 6 months after they catch the virus, according to a massive study published in the journal Nature.

LONG-HAULERS ARE FIGHTING FOR THEIR FUTURE

Many people with long COVID feel that science is failing them. Neglecting them could make the pandemic even worse.

Study: Survivorship after COVID-19 ICU stay

Our understanding of the epidemiology of the severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2) infection and associated COVID-19 illness continues to evolve. Statistics from early in the pandemic indicate that ~1 in 5 infected individuals are hospitalized, and 1 in 10 may be admitted to an intensive care unit (ICU), with most of these critically ill patients experiencing acute respiratory distress syndrome (ARDS) and requiring mechanical ventilation. 

Study: COVID Symptoms, Symptom Clusters, and Predictors for Becoming a Long-Hauler: Looking for Clarity in the Haze of the Pandemic

Emerging data suggest that the effects of infection with SARS-CoV-2 are far reaching extending beyond those with severe acute disease. Specifically, the presence of persistent symptoms after apparent resolution from COVID-19 have frequently been reported throughout the pandemic by individuals labeled as “long-haulers”.