Tens of thousands of people in the United States have lingering illness following COVID-19. In the US, we call them post-COVID “long haulers.” Currently, the condition they are suffering from is known as “long COVID,” although other names are being proposed.
Numerous variants of SARS-CoV-2-harboring mutations in spike have arisen globally
mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus
SARS-CoV-2 entry is mediated by the spike (S) glycoprotein which contains the receptor-binding domain (RBD) and the N-terminal domain (NTD) as the two main targets of neutralizing antibodies (Abs). A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429) was originally detected in California and is currently spreading throughout the US and 29 additional countries. It is unclear whether antibody responses to SARS-CoV-2 infection or to the prototypic Wuhan-1 isolate-based vaccines will be impacted by the three B.1.427/B.1.429 S mutations: S13I, W152C and L452R.
Long COVID, or what doctors refer to as post-acute sequelae of COVID-19 (PASC), is a condition marked by the continuation of COVID-19 symptoms—or the emergence of new ones—after recovery from acute (or the initial phase of illness of) COVID-19.
The CDC is finalizing new guidelines for doctors on long-haul COVID-19.
Many people with long COVID feel that science is failing them. Neglecting them could make the pandemic even worse.
A new study suggests that many patients with long-term COVID-19 symptoms still experience health issues six months following infection, are survivors with “long haul” disease have a greater risk of dying and use a more significant number of medications than patients who have fully recovered from the virus.
Major study details numerous long-term effects of COVID-19, pointing to massive health burden
Novel coronavirus (COVID-19) symptoms can last weeks or months for some people. These patients, given the name “long haulers”, have in theory recovered from the worst impacts of COVID-19 and have tested negative. However, they still have symptoms. There seems to be no consistent reason for this to happen.