Article: The tragedy of long COVID

Tens of thousands of people in the United States have lingering illness following COVID-19. In the US, we call them post-COVID “long haulers.” Currently, the condition they are suffering from is known as “long COVID,” although other names are being proposed.

Study: Multiple SARS-CoV-2 variants escape neutralization by vaccine-induced humoral immunity

Numerous variants of SARS-CoV-2-harboring mutations in spike have arisen globally
mRNA vaccines elicit potent neutralizing activity against homologous pseudovirus

Study: SARS-CoV-2 immune evasion by variant B.1.427/B.1.429

SARS-CoV-2 entry is mediated by the spike (S) glycoprotein which contains the receptor-binding domain (RBD) and the N-terminal domain (NTD) as the two main targets of neutralizing antibodies (Abs). A novel variant of concern (VOC) named CAL.20C (B.1.427/B.1.429) was originally detected in California and is currently spreading throughout the US and 29 additional countries. It is unclear whether antibody responses to SARS-CoV-2 infection or to the prototypic Wuhan-1 isolate-based vaccines will be impacted by the three B.1.427/B.1.429 S mutations: S13I, W152C and L452R. 

Long COVID (Post-Acute Sequelae of SARS CoV-2 infection, PASC)

Long COVID, or what doctors refer to as post-acute sequelae of COVID-19 (PASC), is a condition marked by the continuation of COVID-19 symptoms—or the emergence of new ones—after recovery from acute (or the initial phase of illness of) COVID-19.

CDC to Issue Guidelines As Long-Haul COVID Numbers Rise

The CDC is finalizing new guidelines for doctors on long-haul COVID-19.

LONG-HAULERS ARE FIGHTING FOR THEIR FUTURE

Many people with long COVID feel that science is failing them. Neglecting them could make the pandemic even worse.

“Long Haul” COVID-19 Associated With More Medication Use, Higher Risk of Death

A new study suggests that many patients with long-term COVID-19 symptoms still experience health issues six months following infection, are survivors with “long haul” disease have a greater risk of dying and use a more significant number of medications than patients who have fully recovered from the virus. 

Study: Among COVID-19 survivors, an increased risk of death, serious illness

Major study details numerous long-term effects of COVID-19, pointing to massive health burden

Study: Long haulers: Why some people experience long-term coronavirus symptoms

Novel coronavirus (COVID-19) symptoms can last weeks or months for some people. These patients, given the name “long haulers”, have in theory recovered from the worst impacts of COVID-19 and have tested negative. However, they still have symptoms. There seems to be no consistent reason for this to happen.