SARS-CoV-2 mutation T478K spreading at alarming speed in Mexico

Several severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern are characterized by mutations in the receptor-binding domain and more significant spike protein that enhance virulence by increasing the affinity of this region to the target ACE2 receptor found on the surface of cells, and could potentially better evade vaccine-generated antibodies that are specific to the wildtype spike protein.